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AUTHOR Lee, Jooyoung,Manavalan, Balachandran,Kuwajima, Kunihiro
TITLE PFDB: A standardized protein folding database with temperature correction
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JOURNAL SCIENTIFIC REPORTS, 2019
ABSTRACT We constructed a standardized protein folding kinetics database (PFDB) in which the logarithmic rate constants of all listed proteins are calculated at the standard temperature (25 degrees C). A temperature correction based on the Eyring-Kramers equation was introduced for proteins whose folding kinetics were originally measured at temperatures other than 25 degrees C. We verified the temperature correction by comparing the logarithmic rate constants predicted and experimentally observed at 25 degrees C for 14 different proteins, and the results demonstrated improvement of the quality of the database. PFDB consists of 141 (89 two-state and 52 non-two-state) single-domain globular proteins, which has the largest number among the currently available databases of protein folding kinetics. PFDB is thus intended to be used as a standard for developing and testing future predictive and theoretical studies of protein folding. PFDB can be accessed from the following link: http://lee.kias.re.kr/similar to bala/PFDB.
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